Use of adenine nucleotide derivatives to assess the potential of exo-active-site-directed reagents as species- or isozyme-specific enzyme inactivators. 2. Isozyme-specific inactivation of a mammalian enzyme and its significance in the possible design of fetal isozyme targeted antineoplastic agents.
Hampton, A
Use of adenine nucleotide derivatives to assess the potential of exo-active-site-directed reagents as species- or isozyme-specific enzyme inactivators. 2. Isozyme-specific inactivation of a mammalian enzyme and its significance in the possible design of fetal isozyme targeted antineoplastic agents. [electronic resource] - Journal of medicinal chemistry Nov 1978 - 1137-40 p. digital
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
0022-2623
10.1021/jm00209a009 doi
Adenine Nucleotides--chemical synthesis
Animals
Antineoplastic Agents--chemical synthesis
Fetus--enzymology
In Vitro Techniques
Isoelectric Focusing
Isoenzymes--antagonists & inhibitors
Kidney--enzymology
Kinetics
Liver--enzymology
Male
Muscles--enzymology
Neoplasms--enzymology
Pyruvate Kinase--antagonists & inhibitors
Rats
Structure-Activity Relationship
Use of adenine nucleotide derivatives to assess the potential of exo-active-site-directed reagents as species- or isozyme-specific enzyme inactivators. 2. Isozyme-specific inactivation of a mammalian enzyme and its significance in the possible design of fetal isozyme targeted antineoplastic agents. [electronic resource] - Journal of medicinal chemistry Nov 1978 - 1137-40 p. digital
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
0022-2623
10.1021/jm00209a009 doi
Adenine Nucleotides--chemical synthesis
Animals
Antineoplastic Agents--chemical synthesis
Fetus--enzymology
In Vitro Techniques
Isoelectric Focusing
Isoenzymes--antagonists & inhibitors
Kidney--enzymology
Kinetics
Liver--enzymology
Male
Muscles--enzymology
Neoplasms--enzymology
Pyruvate Kinase--antagonists & inhibitors
Rats
Structure-Activity Relationship