Synthesis and anticholinergic properties of the enantiomers of 4-(isopropylamino)-2-(2-pyridyl)-2-phenylbutyramide, the mono-N-dealkylated metabolite of disopyramide.

Nelson, W L

Synthesis and anticholinergic properties of the enantiomers of 4-(isopropylamino)-2-(2-pyridyl)-2-phenylbutyramide, the mono-N-dealkylated metabolite of disopyramide. [electronic resource] - Journal of medicinal chemistry May 1981 - 614-7 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

0022-2623

10.1021/jm00137a024 doi


Acetylcholine--pharmacology
Animals
Chemical Phenomena
Chemistry
Disopyramide--analogs & derivatives
Dose-Response Relationship, Drug
Electric Stimulation
Guinea Pigs
Histamine--pharmacology
In Vitro Techniques
Muscle Contraction--drug effects
Muscle, Smooth--drug effects
Parasympatholytics--chemical synthesis
Pyridines--chemical synthesis
Stereoisomerism