2-Substituted thiazolidine-4(R)-carboxylic acids as prodrugs of L-cysteine. Protection of mice against acetaminophen hepatotoxicity.

Nagasawa, H T

2-Substituted thiazolidine-4(R)-carboxylic acids as prodrugs of L-cysteine. Protection of mice against acetaminophen hepatotoxicity. [electronic resource] - Journal of medicinal chemistry May 1984 - 591-6 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

0022-2623

10.1021/jm00371a006 doi


Acetaminophen--antagonists & inhibitors
Animals
Carbon Radioisotopes
Cysteine--pharmacology
Indicators and Reagents
Kinetics
Liver--drug effects
Male
Mice
Mitochondria, Liver--enzymology
Proline Oxidase--metabolism
Rats
Rats, Inbred Strains
Structure-Activity Relationship
Thiazoles--chemical synthesis