The association of the temperature-sensitive phenotype with viral attenuation in animals and humans: implications for the development and use of live virus vaccines.

Richman, D D

The association of the temperature-sensitive phenotype with viral attenuation in animals and humans: implications for the development and use of live virus vaccines. [electronic resource] - Reviews of infectious diseases - 413-33 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review

0162-0886

10.1093/clinids/1.3.413 doi


Animals
Body Temperature
Humans
Mutation
Phenotype
Temperature
Vaccines, Attenuated
Viral Vaccines
Virulence
Virus Diseases--microbiology
Virus Replication
Viruses--genetics