Methotrexate analogues-27. Dual inhibition of dihydrofolate reductase and folylpolyglutamate synthetase by methotrexate and aminopterin analogues with a gamma-phosphonate group in the side chain.
Rosowsky, A
Methotrexate analogues-27. Dual inhibition of dihydrofolate reductase and folylpolyglutamate synthetase by methotrexate and aminopterin analogues with a gamma-phosphonate group in the side chain. [electronic resource] - Biochemical pharmacology Oct 1986 - 3327-33 p. digital
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
0006-2952
10.1016/0006-2952(86)90431-4 doi
Aminopterin--analogs & derivatives
Animals
Cell Line
Folic Acid Antagonists
Kinetics
Leukemia L1210--drug therapy
Methotrexate--analogs & derivatives
Mice
Peptide Synthases--antagonists & inhibitors
Structure-Activity Relationship
Methotrexate analogues-27. Dual inhibition of dihydrofolate reductase and folylpolyglutamate synthetase by methotrexate and aminopterin analogues with a gamma-phosphonate group in the side chain. [electronic resource] - Biochemical pharmacology Oct 1986 - 3327-33 p. digital
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
0006-2952
10.1016/0006-2952(86)90431-4 doi
Aminopterin--analogs & derivatives
Animals
Cell Line
Folic Acid Antagonists
Kinetics
Leukemia L1210--drug therapy
Methotrexate--analogs & derivatives
Mice
Peptide Synthases--antagonists & inhibitors
Structure-Activity Relationship