The Lysosomotropic Activity of Hydrophobic Weak Base Drugs is Mediated via Their Intercalation into the Lysosomal Membrane.

Stark, Michal

The Lysosomotropic Activity of Hydrophobic Weak Base Drugs is Mediated via Their Intercalation into the Lysosomal Membrane. [electronic resource] - Cells 04 2020

Publication Type: Journal Article

2073-4409

10.3390/cells9051082 doi


Antineoplastic Agents--pharmacology
Cell Line, Tumor
Central Nervous System Agents--analysis
Drug Resistance, Neoplasm--drug effects
Humans
Hydrophobic and Hydrophilic Interactions--drug effects
Intercalating Agents--analysis
Intracellular Membranes
Lysosomes--drug effects
Molecular Dynamics Simulation
Pharmaceutical Preparations--analysis
Sequestering Agents--metabolism