Pentathiepins: A Novel Class of Glutathione Peroxidase 1 Inhibitors that Induce Oxidative Stress, Loss of Mitochondrial Membrane Potential and Apoptosis in Human Cancer Cells.
Behnisch-Cornwell, Steven
Pentathiepins: A Novel Class of Glutathione Peroxidase 1 Inhibitors that Induce Oxidative Stress, Loss of Mitochondrial Membrane Potential and Apoptosis in Human Cancer Cells. [electronic resource] - ChemMedChem 08 2020 - 1515-1528 p. digital
Publication Type: Journal Article
1860-7187
10.1002/cmdc.202000160 doi
Antineoplastic Agents--chemical synthesis
Apoptosis--drug effects
Cell Proliferation--drug effects
Cell Survival--drug effects
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Enzyme Inhibitors--chemical synthesis
Glutathione Peroxidase--antagonists & inhibitors
Heterocyclic Compounds--chemical synthesis
Humans
Membrane Potential, Mitochondrial--drug effects
Molecular Structure
Oxidative Stress--drug effects
Structure-Activity Relationship
Sulfides--chemical synthesis
Tumor Cells, Cultured
Glutathione Peroxidase GPX1
Pentathiepins: A Novel Class of Glutathione Peroxidase 1 Inhibitors that Induce Oxidative Stress, Loss of Mitochondrial Membrane Potential and Apoptosis in Human Cancer Cells. [electronic resource] - ChemMedChem 08 2020 - 1515-1528 p. digital
Publication Type: Journal Article
1860-7187
10.1002/cmdc.202000160 doi
Antineoplastic Agents--chemical synthesis
Apoptosis--drug effects
Cell Proliferation--drug effects
Cell Survival--drug effects
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Enzyme Inhibitors--chemical synthesis
Glutathione Peroxidase--antagonists & inhibitors
Heterocyclic Compounds--chemical synthesis
Humans
Membrane Potential, Mitochondrial--drug effects
Molecular Structure
Oxidative Stress--drug effects
Structure-Activity Relationship
Sulfides--chemical synthesis
Tumor Cells, Cultured
Glutathione Peroxidase GPX1