Novel Human Neutral Sphingomyelinase 2 Inhibitors as Potential Therapeutics for Alzheimer's Disease.

Šála, Michal

Novel Human Neutral Sphingomyelinase 2 Inhibitors as Potential Therapeutics for Alzheimer's Disease. [electronic resource] - Journal of medicinal chemistry 06 2020 - 6028-6056 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1520-4804

10.1021/acs.jmedchem.0c00278 doi


Alzheimer Disease--drug therapy
Animals
Body Weight--drug effects
Brain--metabolism
Disease Models, Animal
Enzyme Inhibitors--chemistry
Exosomes--metabolism
Female
Humans
Male
Mice
Mice, Transgenic
Pyridazines--chemistry
Sphingomyelin Phosphodiesterase--antagonists & inhibitors
Structure-Activity Relationship