Toxicity Induced by a Bispecific T Cell-Redirecting Protein Is Mediated by Both T Cells and Myeloid Cells in Immunocompetent Mice.

Godbersen-Palmer, Claire

Toxicity Induced by a Bispecific T Cell-Redirecting Protein Is Mediated by Both T Cells and Myeloid Cells in Immunocompetent Mice. [electronic resource] - Journal of immunology (Baltimore, Md. : 1950) 06 2020 - 2973-2983 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

1550-6606

10.4049/jimmunol.1901401 doi


Animals
CD3 Complex
CD4-Positive T-Lymphocytes--immunology
CD8-Positive T-Lymphocytes--immunology
Cell Line, Tumor
Clodronic Acid--metabolism
Colonic Neoplasms--immunology
Cytokine Release Syndrome--etiology
Disease Models, Animal
Drug-Related Side Effects and Adverse Reactions
Humans
Interferon-gamma--metabolism
Lymphocyte Activation
Mice
Mice, Inbred C57BL
Mice, Knockout
Myeloid Cells--immunology
NK Cell Lectin-Like Receptor Subfamily K--genetics
Receptors, Chimeric Antigen--genetics
T-Cell Antigen Receptor Specificity