The inducible β5i proteasome subunit contributes to proinsulin degradation in GRP94-deficient β-cells and is overexpressed in type 2 diabetes pancreatic islets.
Khilji, Muhammad Saad
The inducible β5i proteasome subunit contributes to proinsulin degradation in GRP94-deficient β-cells and is overexpressed in type 2 diabetes pancreatic islets. [electronic resource] - American journal of physiology. Endocrinology and metabolism 06 2020 - E892-E900 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1522-1555
10.1152/ajpendo.00372.2019 doi
Animals
Diabetes Mellitus, Type 2--genetics
Endoplasmic Reticulum Stress--genetics
Endoplasmic Reticulum-Associated Degradation--genetics
Female
Gene Knockout Techniques
Humans
Insulin Secretion--genetics
Insulin-Secreting Cells--metabolism
Islets of Langerhans--metabolism
Membrane Glycoproteins--genetics
Middle Aged
Proinsulin--metabolism
Proteasome Endopeptidase Complex--genetics
Protein Folding
Rats
The inducible β5i proteasome subunit contributes to proinsulin degradation in GRP94-deficient β-cells and is overexpressed in type 2 diabetes pancreatic islets. [electronic resource] - American journal of physiology. Endocrinology and metabolism 06 2020 - E892-E900 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1522-1555
10.1152/ajpendo.00372.2019 doi
Animals
Diabetes Mellitus, Type 2--genetics
Endoplasmic Reticulum Stress--genetics
Endoplasmic Reticulum-Associated Degradation--genetics
Female
Gene Knockout Techniques
Humans
Insulin Secretion--genetics
Insulin-Secreting Cells--metabolism
Islets of Langerhans--metabolism
Membrane Glycoproteins--genetics
Middle Aged
Proinsulin--metabolism
Proteasome Endopeptidase Complex--genetics
Protein Folding
Rats