Involvement of MCL1, c-myc, and cyclin D2 protein degradation in ponatinib-induced cytotoxicity against T315I(+) Ph+leukemia cells.
Inoue, Chisato
Involvement of MCL1, c-myc, and cyclin D2 protein degradation in ponatinib-induced cytotoxicity against T315I(+) Ph+leukemia cells. [electronic resource] - Biochemical and biophysical research communications 05 2020 - 1074-1080 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1090-2104
10.1016/j.bbrc.2020.02.165 doi
Antineoplastic Agents--pharmacology
Cell Death--drug effects
Cell Line, Tumor
Cyclin D2--genetics
Drug Resistance, Neoplasm--genetics
Drug Synergism
Glycogen Synthase Kinase 3--antagonists & inhibitors
Humans
Imatinib Mesylate--pharmacology
Imidazoles--pharmacology
Leukemia, Myelogenous, Chronic, BCR-ABL Positive--drug therapy
Leupeptins--pharmacology
Macrocyclic Compounds--pharmacology
Myeloid Cell Leukemia Sequence 1 Protein--antagonists & inhibitors
Phosphatidylinositol 3-Kinases--metabolism
Phosphoinositide-3 Kinase Inhibitors--pharmacology
Phosphorylation
Protein Kinase Inhibitors--pharmacology
Protein Phosphatase 2--metabolism
Proteolysis--drug effects
Proto-Oncogene Proteins c-bcl-2--antagonists & inhibitors
Proto-Oncogene Proteins c-myc--genetics
Pyridazines--pharmacology
Pyrroles--pharmacology
Signal Transduction--drug effects
Wortmannin--pharmacology
Involvement of MCL1, c-myc, and cyclin D2 protein degradation in ponatinib-induced cytotoxicity against T315I(+) Ph+leukemia cells. [electronic resource] - Biochemical and biophysical research communications 05 2020 - 1074-1080 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1090-2104
10.1016/j.bbrc.2020.02.165 doi
Antineoplastic Agents--pharmacology
Cell Death--drug effects
Cell Line, Tumor
Cyclin D2--genetics
Drug Resistance, Neoplasm--genetics
Drug Synergism
Glycogen Synthase Kinase 3--antagonists & inhibitors
Humans
Imatinib Mesylate--pharmacology
Imidazoles--pharmacology
Leukemia, Myelogenous, Chronic, BCR-ABL Positive--drug therapy
Leupeptins--pharmacology
Macrocyclic Compounds--pharmacology
Myeloid Cell Leukemia Sequence 1 Protein--antagonists & inhibitors
Phosphatidylinositol 3-Kinases--metabolism
Phosphoinositide-3 Kinase Inhibitors--pharmacology
Phosphorylation
Protein Kinase Inhibitors--pharmacology
Protein Phosphatase 2--metabolism
Proteolysis--drug effects
Proto-Oncogene Proteins c-bcl-2--antagonists & inhibitors
Proto-Oncogene Proteins c-myc--genetics
Pyridazines--pharmacology
Pyrroles--pharmacology
Signal Transduction--drug effects
Wortmannin--pharmacology