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Interdomain spacing and spatial configuration drive the potency of IgG-[L]-scFv T cell bispecific antibodies.

Santich, Brian H

Interdomain spacing and spatial configuration drive the potency of IgG-[L]-scFv T cell bispecific antibodies. [electronic resource] - Science translational medicine 03 2020

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

ISSN: 1946-6242

Standard No.: 10.1126/scitranslmed.aax1315 doi

Subjects--Topical Terms:
Antibodies, Bispecific
CD3 Complex
Humans
Immunoglobulin G
Neoplasms
Single-Chain Antibodies
T-Lymphocytes, Cytotoxic

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