Acetate supplementation restores chromatin accessibility and promotes tumor cell differentiation under hypoxia.

Li, Yang

Acetate supplementation restores chromatin accessibility and promotes tumor cell differentiation under hypoxia. [electronic resource] - Cell death & disease 02 2020 - 102 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

2041-4889

10.1038/s41419-020-2303-9 doi


Acetates--pharmacology
Acetylation
Animals
Antineoplastic Agents--pharmacology
Cell Line, Tumor
Chromatin Assembly and Disassembly--drug effects
Gene Expression Regulation, Neoplastic
Histones--metabolism
Humans
Male
Mice
Neuroblastoma--drug therapy
Neurogenesis--drug effects
Neuronal Outgrowth--drug effects
Pyruvate Dehydrogenase Acetyl-Transferring Kinase--genetics
Signal Transduction
Tumor Burden--drug effects
Tumor Hypoxia
Tumor Microenvironment
Warburg Effect, Oncologic--drug effects
Xenograft Model Antitumor Assays