A cellular target engagement assay for the characterization of SHP2 (PTPN11) phosphatase inhibitors.

Romero, Celeste

A cellular target engagement assay for the characterization of SHP2 (PTPN11) phosphatase inhibitors. [electronic resource] - The Journal of biological chemistry 02 2020 - 2601-2613 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1083-351X

10.1074/jbc.RA119.010838 doi


Animals
Carcinogenesis--genetics
Cell Line
Drug Discovery--methods
Enzyme Inhibitors--metabolism
Gain of Function Mutation
Humans
Protein Binding
Protein Tyrosine Phosphatase, Non-Receptor Type 11--antagonists & inhibitors
Proto-Oncogene Mas