All-trans retinoic acid exerts selective anti-FLT3-ITD acute myeloid leukemia efficacy through downregulating Chk1 kinase.

Wang, Wenliang

All-trans retinoic acid exerts selective anti-FLT3-ITD acute myeloid leukemia efficacy through downregulating Chk1 kinase. [electronic resource] - Cancer letters 03 2020 - 130-138 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1872-7980

10.1016/j.canlet.2019.12.045 doi


Adult
Aged
Animals
Antineoplastic Combined Chemotherapy Protocols--pharmacology
Apoptosis--drug effects
Cell Line, Tumor
Checkpoint Kinase 1--antagonists & inhibitors
Child, Preschool
DNA Damage--drug effects
DNA Repair--drug effects
Down-Regulation--drug effects
Drug Synergism
Gene Expression Regulation, Leukemic--drug effects
Humans
Irinotecan--pharmacology
Leukemia, Myeloid, Acute--blood
Male
Mice
Middle Aged
Mitosis--drug effects
Primary Cell Culture
Protein Kinase Inhibitors--pharmacology
Tandem Repeat Sequences--genetics
Topoisomerase I Inhibitors--pharmacology
Tretinoin--pharmacology
Xenograft Model Antitumor Assays
fms-Like Tyrosine Kinase 3--genetics