Indoleamine 2,3-dioxgenase-transfected mesenchymal stem cells suppress heart allograft rejection by increasing the production and activity of dendritic cells and regulatory T cells.

He, Ji-Gang

Indoleamine 2,3-dioxgenase-transfected mesenchymal stem cells suppress heart allograft rejection by increasing the production and activity of dendritic cells and regulatory T cells. [electronic resource] - Journal of investigative medicine : the official publication of the American Federation for Clinical Research 03 2020 - 728-737 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1708-8267

10.1136/jim-2019-001160 doi


Allografts
Animals
Bone Marrow Cells
Cells, Cultured
Coculture Techniques
Cytokines--metabolism
Dendritic Cells--metabolism
Graft Rejection--prevention & control
Heart Transplantation
Indoleamine-Pyrrole 2,3,-Dioxygenase--immunology
Interleukin-10--metabolism
Lentivirus--genetics
Male
Mesenchymal Stem Cells--drug effects
Rats
Rats, Sprague-Dawley
Rats, Wistar
Stem Cells--metabolism
T-Lymphocytes, Regulatory--metabolism
Transfection
Transplantation Tolerance