Novel engineered TRAIL-based chimeric protein strongly inhibits tumor growth and bypasses TRAIL resistance.

Rozga, Piotr

Novel engineered TRAIL-based chimeric protein strongly inhibits tumor growth and bypasses TRAIL resistance. [electronic resource] - International journal of cancer 08 2020 - 1117-1130 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1097-0215

10.1002/ijc.32845 doi


A549 Cells
Animals
Antineoplastic Agents--metabolism
Apoptosis--drug effects
Cell Line, Tumor
Cell Proliferation--drug effects
Drug Resistance, Neoplasm--drug effects
Female
HCT116 Cells
HT29 Cells
Hep G2 Cells
Humans
Mice, SCID
Neoplasms--drug therapy
Protein Engineering--methods
Recombinant Fusion Proteins--genetics
TNF-Related Apoptosis-Inducing Ligand--genetics
Tumor Burden--drug effects
Xenograft Model Antitumor Assays--methods