Pharmacological inhibition of TAK1, with the selective inhibitor takinib, alleviates clinical manifestation of arthritis in CIA mice.

Scarneo, Scott A

Pharmacological inhibition of TAK1, with the selective inhibitor takinib, alleviates clinical manifestation of arthritis in CIA mice. [electronic resource] - Arthritis research & therapy 12 2019 - 292 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

1478-6362

10.1186/s13075-019-2073-x doi


Animals
Arthritis, Experimental--metabolism
Arthritis, Rheumatoid--metabolism
Benzamides--pharmacokinetics
Benzimidazoles--pharmacokinetics
Cells, Cultured
Cytokines--metabolism
Disease Models, Animal
Fibroblasts--drug effects
Humans
Inflammation--metabolism
Knee Joint--drug effects
MAP Kinase Kinase Kinases--antagonists & inhibitors
Mice, Inbred DBA
Protein Kinase Inhibitors--pharmacology
Severity of Illness Index
Synoviocytes--drug effects