Synthesis, molecular docking, dynamic simulations, kinetic mechanism, cytotoxicity evaluation of N-(substituted-phenyl)-4-{(4-[(E)-3-phenyl-2-propenyl]-1-piperazinyl} butanamides as tyrosinase and melanin inhibitors: In vitro, in vivo and in silico approaches.

Raza, Hussain

Synthesis, molecular docking, dynamic simulations, kinetic mechanism, cytotoxicity evaluation of N-(substituted-phenyl)-4- butanamides as tyrosinase and melanin inhibitors: In vitro, in vivo and in silico approaches. [electronic resource] - Bioorganic chemistry 01 2020 - 103445 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1090-2120

10.1016/j.bioorg.2019.103445 doi


Amides--chemical synthesis
Animals
Dose-Response Relationship, Drug
Enzyme Inhibitors--chemical synthesis
Melanins--antagonists & inhibitors
Models, Molecular
Molecular Structure
Monophenol Monooxygenase--antagonists & inhibitors
Piperazine--chemical synthesis
Structure-Activity Relationship
Zebrafish