Sidechain Diversification of Grandifloracin Allows Identification of Analogues with Enhanced Anti-Austerity Activity against Human PANC-1 Pancreatic Cancer Cells.

Alexander, Benjamin E

Sidechain Diversification of Grandifloracin Allows Identification of Analogues with Enhanced Anti-Austerity Activity against Human PANC-1 Pancreatic Cancer Cells. [electronic resource] - ChemMedChem 01 2020 - 125-135 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1860-7187

10.1002/cmdc.201900549 doi


Antineoplastic Agents, Phytogenic--chemical synthesis
Biological Products--chemical synthesis
Bridged-Ring Compounds--chemical synthesis
Cell Line, Tumor
Cell Survival--drug effects
Crystallography, X-Ray
Humans
Molecular Conformation
Pancreatic Neoplasms--metabolism
Stereoisomerism