A novel dual reporter embryonic stem cell line for toxicological assessment of teratogen-induced perturbation of anterior-posterior patterning of the heart.

Leigh, Robert S

A novel dual reporter embryonic stem cell line for toxicological assessment of teratogen-induced perturbation of anterior-posterior patterning of the heart. [electronic resource] - Archives of toxicology 02 2020 - 631-645 p. digital

Publication Type: Journal Article

1432-0738

10.1007/s00204-019-02632-1 doi


Animals
Body Patterning--drug effects
Cell Differentiation--drug effects
Cell Line
Female
Gene Editing
Gene Expression Regulation, Developmental
Genes, Reporter
Green Fluorescent Proteins--genetics
Heart--drug effects
Mice
Mice, Inbred C57BL
Mice, Transgenic
Mouse Embryonic Stem Cells--cytology
Myocytes, Cardiac--cytology
Myosin Light Chains--genetics
Pregnancy
Retinoids--pharmacology
Teratogens--toxicity
Toxicity Tests--methods