Inhibition of the histone demethylase, KDM5B, directly induces re-expression of tumor suppressor protein HEXIM1 in cancer cells.

Montano, Monica M

Inhibition of the histone demethylase, KDM5B, directly induces re-expression of tumor suppressor protein HEXIM1 in cancer cells. [electronic resource] - Breast cancer research : BCR 12 2019 - 138 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

1465-542X

10.1186/s13058-019-1228-7 doi


Biomarkers, Tumor
Breast Neoplasms--etiology
Cell Differentiation
Cell Line, Tumor
Cell Proliferation
Female
Gene Expression Regulation, Neoplastic--drug effects
Histones--metabolism
Humans
Jumonji Domain-Containing Histone Demethylases--antagonists & inhibitors
Kaplan-Meier Estimate
Models, Molecular
Neoplasm Staging
Nuclear Proteins--antagonists & inhibitors
Promoter Regions, Genetic
Protein Binding
RNA-Binding Proteins--chemistry
Recurrence
Repressor Proteins--antagonists & inhibitors
Structure-Activity Relationship
Transcription Factors--chemistry