Optimization of cyclic sulfamide derivatives as 11β-hydroxysteroid dehydrogenase 1 inhibitors for the potential treatment of ischemic brain injury.

Lee, Jeong Hyun

Optimization of cyclic sulfamide derivatives as 11β-hydroxysteroid dehydrogenase 1 inhibitors for the potential treatment of ischemic brain injury. [electronic resource] - Bioorganic & medicinal chemistry letters 01 2020 - 126787 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1464-3405

10.1016/j.bmcl.2019.126787 doi


11-beta-Hydroxysteroid Dehydrogenase Type 1--antagonists & inhibitors
Amides--chemistry
Animals
Brain--metabolism
Brain Injuries--drug therapy
Cyclization
Enzyme Inhibitors--chemistry
Humans
Infarction, Middle Cerebral Artery--drug therapy
Injections, Intraperitoneal
Mice
Structure-Activity Relationship