Localized controlled release of bevacizumab and doxorubicin by thermo-sensitive hydrogel for normalization of tumor vasculature and to enhance the efficacy of chemotherapy.

Darge, Haile Fentahun

Localized controlled release of bevacizumab and doxorubicin by thermo-sensitive hydrogel for normalization of tumor vasculature and to enhance the efficacy of chemotherapy. [electronic resource] - International journal of pharmaceutics Dec 2019 - 118799 p. digital

Publication Type: Journal Article

1873-3476

10.1016/j.ijpharm.2019.118799 doi


Angiogenesis Inhibitors--administration & dosage
Animals
Antibiotics, Antineoplastic--administration & dosage
Antineoplastic Combined Chemotherapy Protocols--administration & dosage
Bevacizumab--administration & dosage
Delayed-Action Preparations
Doxorubicin--administration & dosage
Drug Carriers
Drug Compounding
Drug Liberation
Female
HeLa Cells
Humans
Hydrogels
Hydrogen-Ion Concentration
Mice, Inbred BALB C
Mice, Nude
Neovascularization, Pathologic
Polyesters--chemistry
Polyethylene Glycols--chemistry
Stimuli Responsive Polymers--chemistry
Temperature
Uterine Cervical Neoplasms--blood supply
Xenograft Model Antitumor Assays