Endothelial cell pyroptosis plays an important role in Kawasaki disease via HMGB1/RAGE/cathespin B signaling pathway and NLRP3 inflammasome activation.

Jia, Chang

Endothelial cell pyroptosis plays an important role in Kawasaki disease via HMGB1/RAGE/cathespin B signaling pathway and NLRP3 inflammasome activation. [electronic resource] - Cell death & disease 10 2019 - 778 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

2041-4889

10.1038/s41419-019-2021-3 doi


Animals
Antigens, Neoplasm--genetics
Candida albicans--pathogenicity
Caspase 1--genetics
Cathepsins--genetics
Disease Models, Animal
Endothelial Cells--metabolism
HMGB1 Protein--genetics
Human Umbilical Vein Endothelial Cells
Humans
Inflammasomes--genetics
Interleukin-18--genetics
Interleukin-1beta--genetics
Intracellular Signaling Peptides and Proteins--genetics
Mice
Mitogen-Activated Protein Kinases--genetics
Mucocutaneous Lymph Node Syndrome--genetics
NLR Family, Pyrin Domain-Containing 3 Protein--genetics
Phosphate-Binding Proteins--genetics
Pyroptosis--genetics
Reactive Oxygen Species--metabolism
Signal Transduction--genetics