ZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancer.

Kanakkanthara, Arun

ZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancer. [electronic resource] - Nature communications 10 2019 - 4632 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

2041-1723

10.1038/s41467-019-12610-x doi


BRCA1 Protein--genetics
Cell Line, Tumor
DNA Damage
DNA Methylation
Female
Gene Expression Regulation, Neoplastic
Homologous Recombination
Humans
Ovarian Neoplasms--genetics
Promoter Regions, Genetic
RNA-Binding Proteins--metabolism
Transcription, Genetic