Maladaptive activation of Nav1.9 channels by nitric oxide causes triptan-induced medication overuse headache.

Bonnet, Caroline

Maladaptive activation of Nav1.9 channels by nitric oxide causes triptan-induced medication overuse headache. [electronic resource] - Nature communications 09 2019 - 4253 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

2041-1723

10.1038/s41467-019-12197-3 doi


Animals
Calcitonin Gene-Related Peptide--metabolism
Cell Degranulation--physiology
Cells, Cultured
Female
Headache Disorders, Secondary--chemically induced
Hyperalgesia--physiopathology
Male
Mast Cells--pathology
Mice
Mice, Inbred C57BL
Mice, Knockout
Migraine Disorders--pathology
NAV1.9 Voltage-Gated Sodium Channel--genetics
Neurons, Afferent--drug effects
Nitric Oxide--metabolism
Nociceptors--physiology
Pain--physiopathology
Prescription Drug Overuse--adverse effects
Tryptamines--adverse effects