MCM8- and MCM9 Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53-Dependent Myeloid Tumors.

Lutzmann, Malik

MCM8- and MCM9 Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53-Dependent Myeloid Tumors. [electronic resource] - Cell reports Sep 2019 - 2851-2865.e4 p. digital

Publication Type: Journal Article

2211-1247

10.1016/j.celrep.2019.07.095 doi


Aging--genetics
Animals
Apoptosis--genetics
Bone Marrow--metabolism
Cell Differentiation--genetics
Cell Proliferation--genetics
DNA Damage--genetics
Gene Expression Regulation, Leukemic--genetics
Hematologic Neoplasms--genetics
Mice
Mice, Knockout
Minichromosome Maintenance Proteins--genetics
Retinoblastoma Protein--genetics
Signal Transduction--genetics
Splenomegaly--genetics
Tumor Suppressor Protein p53--genetics