Engineering a Polyspecific Pyrrolysyl-tRNA Synthetase by a High Throughput FACS Screen.

Hohl, Adrian

Engineering a Polyspecific Pyrrolysyl-tRNA Synthetase by a High Throughput FACS Screen. [electronic resource] - Scientific reports 08 2019 - 11971 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

2045-2322

10.1038/s41598-019-48357-0 doi


Amino Acyl-tRNA Synthetases--chemistry
Flow Cytometry--methods
Gene Library
High-Throughput Screening Assays
Lysine--analogs & derivatives
Molecular Conformation
Molecular Docking Simulation
Molecular Dynamics Simulation
Protein Engineering
Structure-Activity Relationship
Substrate Specificity