TLR4 deficiency has a protective effect in the MPTP/probenecid mouse model of Parkinson's disease.

Shao, Qian-Hang

TLR4 deficiency has a protective effect in the MPTP/probenecid mouse model of Parkinson's disease. [electronic resource] - Acta pharmacologica Sinica Dec 2019 - 1503-1512 p. digital

Publication Type: Journal Article

1745-7254

10.1038/s41401-019-0280-2 doi


1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Animals
Astrocytes--metabolism
Corpus Striatum--metabolism
Dopaminergic Neurons--metabolism
Inflammasomes--metabolism
Male
Mice, Inbred C57BL
Mice, Knockout
Microglia--metabolism
NF-kappa B p50 Subunit--metabolism
NLR Family, Pyrin Domain-Containing 3 Protein--metabolism
Parkinson Disease, Secondary--chemically induced
Pars Compacta--metabolism
Probenecid
Signal Transduction--physiology
Toll-Like Receptor 4--genetics
Tyrosine 3-Monooxygenase--metabolism
alpha-Synuclein--metabolism