Cathepsin B increases ENaC activity leading to hypertension early in nephrotic syndrome.

Larionov, Alexey

Cathepsin B increases ENaC activity leading to hypertension early in nephrotic syndrome. [electronic resource] - Journal of cellular and molecular medicine 10 2019 - 6543-6553 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1582-4934

10.1111/jcmm.14387 doi


Amiloride--pharmacology
Animals
Cathepsin B--antagonists & inhibitors
Epithelial Sodium Channel Blockers--pharmacology
Epithelial Sodium Channels--metabolism
Glomerulosclerosis, Focal Segmental--enzymology
Hypertension--etiology
Intracellular Signaling Peptides and Proteins--genetics
Kidney Tubules--cytology
Lysosomes--enzymology
Membrane Proteins--genetics
Mice
Mice, Transgenic
Nephrotic Syndrome--complications
Proteinuria--metabolism
Proteolysis
Sodium--metabolism