Rapid Screen for Tyrosine Kinase Inhibitor Resistance Mutations and Substrate Specificity.
Taft, Joseph M
Rapid Screen for Tyrosine Kinase Inhibitor Resistance Mutations and Substrate Specificity. [electronic resource] - ACS chemical biology 09 2019 - 1888-1895 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1554-8937
10.1021/acschembio.9b00283 doi
Antibodies--chemistry
Cell Adhesion Molecules--immunology
Dasatinib--pharmacology
Drug Resistance--physiology
Flow Cytometry--methods
Fluorescent Dyes--chemistry
High-Throughput Screening Assays--methods
Humans
Imidazoles--pharmacology
Machine Learning
Mutation
Phosphorylation--drug effects
Proof of Concept Study
Protein Kinase Inhibitors--pharmacology
Proto-Oncogene Proteins c-abl--antagonists & inhibitors
Pyridazines--pharmacology
Recombinant Fusion Proteins--immunology
Saccharomyces cerevisiae--chemistry
Saccharomyces cerevisiae Proteins--immunology
Substrate Specificity
Rapid Screen for Tyrosine Kinase Inhibitor Resistance Mutations and Substrate Specificity. [electronic resource] - ACS chemical biology 09 2019 - 1888-1895 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1554-8937
10.1021/acschembio.9b00283 doi
Antibodies--chemistry
Cell Adhesion Molecules--immunology
Dasatinib--pharmacology
Drug Resistance--physiology
Flow Cytometry--methods
Fluorescent Dyes--chemistry
High-Throughput Screening Assays--methods
Humans
Imidazoles--pharmacology
Machine Learning
Mutation
Phosphorylation--drug effects
Proof of Concept Study
Protein Kinase Inhibitors--pharmacology
Proto-Oncogene Proteins c-abl--antagonists & inhibitors
Pyridazines--pharmacology
Recombinant Fusion Proteins--immunology
Saccharomyces cerevisiae--chemistry
Saccharomyces cerevisiae Proteins--immunology
Substrate Specificity