Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database.

Dominguez-Valentin, Mev

Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database. [electronic resource] - Genetics in medicine : official journal of the American College of Medical Genetics 01 2020 - 15-25 p. digital

Publication Type: Journal Article; Multicenter Study; Observational Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1530-0366

10.1038/s41436-019-0596-9 doi


Adult
Aged
Colorectal Neoplasms, Hereditary Nonpolyposis--genetics
DNA Mismatch Repair
DNA-Binding Proteins--economics
Databases, Genetic
Female
Genetic Predisposition to Disease
Humans
Male
Middle Aged
Mismatch Repair Endonuclease PMS2--genetics
MutL Protein Homolog 1--genetics
MutS Homolog 2 Protein--genetics
Mutation
Penetrance
Prospective Studies
Risk Assessment
Sex Characteristics
Survival Analysis