Divergent Polypharmacology-Driven Cellular Activity of Structurally Similar Multi-Kinase Inhibitors through Cumulative Effects on Individual Targets.

Sumi, Natalia J

Divergent Polypharmacology-Driven Cellular Activity of Structurally Similar Multi-Kinase Inhibitors through Cumulative Effects on Individual Targets. [electronic resource] - Cell chemical biology 09 2019 - 1240-1252.e11 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

2451-9448

10.1016/j.chembiol.2019.06.003 doi


Anilides--pharmacology
Antineoplastic Combined Chemotherapy Protocols--metabolism
Aurora Kinase B--metabolism
Cell Line, Tumor
Drug Discovery
Humans
Lung Neoplasms--drug therapy
MAP Kinase Kinase 1--metabolism
MAP Kinase Kinase 2--metabolism
Organophosphates--pharmacology
Polypharmacology
Protein Kinase Inhibitors--chemistry
Protein-Tyrosine Kinases--metabolism
Pyridines--pharmacology
Quinazolines--pharmacology
Quinolines--pharmacology
Systems Analysis