Discovery of novel CBP bromodomain inhibitors through TR-FRET-based high-throughput screening.

Zhang, Feng-Cai

Discovery of novel CBP bromodomain inhibitors through TR-FRET-based high-throughput screening. [electronic resource] - Acta pharmacologica Sinica Feb 2020 - 286-292 p. digital

Publication Type: Journal Article

1745-7254

10.1038/s41401-019-0256-2 doi


Antineoplastic Agents--administration & dosage
Binding Sites
CREB-Binding Protein--antagonists & inhibitors
Cell Line, Tumor
Cell Proliferation--drug effects
Dose-Response Relationship, Drug
Drug Discovery--methods
Fluorescence Resonance Energy Transfer
High-Throughput Screening Assays
Humans
Inhibitory Concentration 50
Leukemia--drug therapy
Models, Molecular
Protein Domains
Small Molecule Libraries