RRx-001 protects normal tissues but not tumors via Nrf2 induction and Bcl-2 inhibition.
Oronsky, Bryan
RRx-001 protects normal tissues but not tumors via Nrf2 induction and Bcl-2 inhibition. [electronic resource] - Journal of cancer research and clinical oncology Aug 2019 - 2045-2050 p. digital
Publication Type: Journal Article
1432-1335
10.1007/s00432-019-02958-4 doi
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Azetidines--pharmacology
Caco-2 Cells
Cell Line, Tumor
Cytoprotection--drug effects
Gene Expression Regulation, Neoplastic--drug effects
HCT116 Cells
Humans
NF-E2-Related Factor 2--genetics
Neoplasms--genetics
Nitro Compounds--pharmacology
Proto-Oncogene Proteins c-bcl-2--genetics
RRx-001 protects normal tissues but not tumors via Nrf2 induction and Bcl-2 inhibition. [electronic resource] - Journal of cancer research and clinical oncology Aug 2019 - 2045-2050 p. digital
Publication Type: Journal Article
1432-1335
10.1007/s00432-019-02958-4 doi
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Azetidines--pharmacology
Caco-2 Cells
Cell Line, Tumor
Cytoprotection--drug effects
Gene Expression Regulation, Neoplastic--drug effects
HCT116 Cells
Humans
NF-E2-Related Factor 2--genetics
Neoplasms--genetics
Nitro Compounds--pharmacology
Proto-Oncogene Proteins c-bcl-2--genetics