Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether.
Torres, Sandra Elizabeth
Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether. [electronic resource] - eLife 05 2019
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
2050-084X
10.7554/eLife.46595 doi
ATP-Binding Cassette Transporters--metabolism
Activating Transcription Factor 6--antagonists & inhibitors
CRISPR-Cas Systems--genetics
Endoplasmic Reticulum--drug effects
HEK293 Cells
Hep G2 Cells
Humans
Organelles--drug effects
Peroxisomes--drug effects
Phenotype
Protein Binding--drug effects
Small Molecule Libraries--pharmacology
Unfolded Protein Response--drug effects
Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether. [electronic resource] - eLife 05 2019
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
2050-084X
10.7554/eLife.46595 doi
ATP-Binding Cassette Transporters--metabolism
Activating Transcription Factor 6--antagonists & inhibitors
CRISPR-Cas Systems--genetics
Endoplasmic Reticulum--drug effects
HEK293 Cells
Hep G2 Cells
Humans
Organelles--drug effects
Peroxisomes--drug effects
Phenotype
Protein Binding--drug effects
Small Molecule Libraries--pharmacology
Unfolded Protein Response--drug effects