A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity.

van der Lee, Sven J

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity. [electronic resource] - Acta neuropathologica 08 2019 - 237-250 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1432-0533

10.1007/s00401-019-02026-8 doi


Alleles
Alzheimer Disease--genetics
Amyotrophic Lateral Sclerosis--genetics
Brain--immunology
Dementia--genetics
Frontotemporal Dementia--genetics
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Lewy Body Disease--genetics
Longevity--genetics
Microglia--metabolism
Multiple Sclerosis--genetics
Mutation
Neuroimaging
Parkinson Disease--genetics
Phospholipase C gamma--genetics
Risk