Discovery and synthesis of novel indole derivatives-containing 3-methylenedihydrofuran-2(3H)-one as irreversible LSD1 inhibitors.

Liu, Hong-Min

Discovery and synthesis of novel indole derivatives-containing 3-methylenedihydrofuran-2(3H)-one as irreversible LSD1 inhibitors. [electronic resource] - European journal of medicinal chemistry Aug 2019 - 357-372 p. digital

Publication Type: Journal Article

1768-3254

10.1016/j.ejmech.2019.04.065 doi


Cell Line
Cell Proliferation--drug effects
Drug Discovery
Enzyme Inhibitors--chemical synthesis
Furans--chemistry
High-Throughput Screening Assays
Histone Demethylases--antagonists & inhibitors
Humans
Indoles--chemical synthesis
Inhibitory Concentration 50
Leukemia, Myeloid, Acute--pathology
Recombinant Proteins--drug effects
Structure-Activity Relationship