Design, Synthesis, and Biological Evaluation of a New Series of Carvedilol Derivatives That Protect Sensory Hair Cells from Aminoglycoside-Induced Damage by Blocking the Mechanoelectrical Transducer Channel.
O'Reilly, Molly
Design, Synthesis, and Biological Evaluation of a New Series of Carvedilol Derivatives That Protect Sensory Hair Cells from Aminoglycoside-Induced Damage by Blocking the Mechanoelectrical Transducer Channel. [electronic resource] - Journal of medicinal chemistry 06 2019 - 5312-5329 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1520-4804
10.1021/acs.jmedchem.8b01325 doi
Aminoglycosides--adverse effects
Animals
Carvedilol--chemical synthesis
Chemistry Techniques, Synthetic
Cytoprotection--drug effects
Dose-Response Relationship, Drug
Drug Design
Electrophysiological Phenomena--drug effects
Hair Cells, Auditory--cytology
Mechanotransduction, Cellular--drug effects
Mice
Zebrafish
Design, Synthesis, and Biological Evaluation of a New Series of Carvedilol Derivatives That Protect Sensory Hair Cells from Aminoglycoside-Induced Damage by Blocking the Mechanoelectrical Transducer Channel. [electronic resource] - Journal of medicinal chemistry 06 2019 - 5312-5329 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1520-4804
10.1021/acs.jmedchem.8b01325 doi
Aminoglycosides--adverse effects
Animals
Carvedilol--chemical synthesis
Chemistry Techniques, Synthetic
Cytoprotection--drug effects
Dose-Response Relationship, Drug
Drug Design
Electrophysiological Phenomena--drug effects
Hair Cells, Auditory--cytology
Mechanotransduction, Cellular--drug effects
Mice
Zebrafish