Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK Activation.

Vara-Ciruelos, Diana

Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK Activation. [electronic resource] - Cell reports 04 2019 - 690-698.e4 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

2211-1247

10.1016/j.celrep.2019.03.067 doi


AMP-Activated Protein Kinases--deficiency
Administration, Oral
Animals
Cell Proliferation--drug effects
Disease Models, Animal
Disease-Free Survival
Female
Glycolysis--drug effects
Hypoglycemic Agents--pharmacology
Male
Mechanistic Target of Rapamycin Complex 1--antagonists & inhibitors
Metformin--pharmacology
Mice
Mice, Inbred C57BL
Mice, Knockout
PTEN Phosphohydrolase--deficiency
Phenformin--pharmacology
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma--drug therapy
Signal Transduction--drug effects
Sirolimus--pharmacology