PARP Inhibitor Protects Against Chronic Hypoxia/Reoxygenation-Induced Retinal Injury by Regulation of MAPKs, HIF1α, Nrf2, and NFκB.

Kovacs, Krisztina

PARP Inhibitor Protects Against Chronic Hypoxia/Reoxygenation-Induced Retinal Injury by Regulation of MAPKs, HIF1α, Nrf2, and NFκB. [electronic resource] - Investigative ophthalmology & visual science 04 2019 - 1478-1490 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1552-5783

10.1167/iovs.18-25936 doi


Animals
Chronic Disease
Cytokines--metabolism
Disease Models, Animal
Fluorescent Antibody Technique, Indirect
Hypoxia--complications
Hypoxia-Inducible Factor 1, alpha Subunit--metabolism
Immunoblotting
Intercellular Signaling Peptides and Proteins--metabolism
Male
NF-E2-Related Factor 2--metabolism
NF-kappa B--metabolism
Oxidative Stress
Oxygen--toxicity
Phosphorylation
Phthalazines--therapeutic use
Piperazines--therapeutic use
Poly (ADP-Ribose) Polymerase-1--antagonists & inhibitors
Poly(ADP-ribose) Polymerase Inhibitors--therapeutic use
Rats
Rats, Wistar
Reactive Oxygen Species--metabolism
Reperfusion Injury--metabolism
Retinal Diseases--metabolism
p38 Mitogen-Activated Protein Kinases--metabolism