Estimation of competitive antagonist affinity by the Schild method and from functional inhibition curves using a novel form of the Gaddum equation.

Ezechiáš, Martin

Estimation of competitive antagonist affinity by the Schild method and from functional inhibition curves using a novel form of the Gaddum equation. [electronic resource] - Toxicology 05 2019 - 21-28 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

1879-3185

10.1016/j.tox.2019.03.015 doi


Animals
Benzhydryl Compounds--metabolism
Binding, Competitive
Dose-Response Relationship, Drug
Drug Partial Agonism
Endocrine Disruptors--metabolism
Estradiol--metabolism
Estrogen Receptor Antagonists--metabolism
Estrogen Receptor alpha--antagonists & inhibitors
Estrogens--metabolism
Humans
Ligands
Models, Biological
Phenols--metabolism
Protein Binding
Reproducibility of Results