Preclinical in vivo characterization of lemborexant (E2006), a novel dual orexin receptor antagonist for sleep/wake regulation.

Beuckmann, Carsten Theodor

Preclinical in vivo characterization of lemborexant (E2006), a novel dual orexin receptor antagonist for sleep/wake regulation. [electronic resource] - Sleep 06 2019

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1550-9109

10.1093/sleep/zsz076 doi


Acetamides--pharmacology
Adrenocorticotropic Hormone--blood
Animals
Female
Hypnotics and Sedatives--pharmacology
Isoquinolines--pharmacology
Male
Mice
Mice, Inbred C57BL
Orexin Receptor Antagonists--pharmacology
Orexin Receptors--metabolism
Pyridines--pharmacology
Pyrimidines--pharmacology
Rats
Rats, Sprague-Dawley
Sleep Initiation and Maintenance Disorders--drug therapy
Sleep, REM--drug effects
Wakefulness--physiology
Zolpidem--pharmacology