Intrinsic cell-penetrating activity propels Omomyc from proof of concept to viable anti-MYC therapy.
Beaulieu, Marie-Eve
Intrinsic cell-penetrating activity propels Omomyc from proof of concept to viable anti-MYC therapy. [electronic resource] - Science translational medicine 03 2019
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1946-6242
10.1126/scitranslmed.aar5012 doi
Adenocarcinoma of Lung--drug therapy
Animals
Basic-Leucine Zipper Transcription Factors--metabolism
Carcinoma, Non-Small-Cell Lung--drug therapy
Cell Line, Tumor
Cell-Penetrating Peptides--pharmacokinetics
DNA--metabolism
Disease Models, Animal
E-Box Elements--genetics
Female
Humans
Lung Neoplasms--drug therapy
Mice, Inbred C57BL
Peptide Fragments--administration & dosage
Promoter Regions, Genetic--genetics
Protein Binding--drug effects
Protein Multimerization--drug effects
Proto-Oncogene Proteins c-myc--administration & dosage
Intrinsic cell-penetrating activity propels Omomyc from proof of concept to viable anti-MYC therapy. [electronic resource] - Science translational medicine 03 2019
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1946-6242
10.1126/scitranslmed.aar5012 doi
Adenocarcinoma of Lung--drug therapy
Animals
Basic-Leucine Zipper Transcription Factors--metabolism
Carcinoma, Non-Small-Cell Lung--drug therapy
Cell Line, Tumor
Cell-Penetrating Peptides--pharmacokinetics
DNA--metabolism
Disease Models, Animal
E-Box Elements--genetics
Female
Humans
Lung Neoplasms--drug therapy
Mice, Inbred C57BL
Peptide Fragments--administration & dosage
Promoter Regions, Genetic--genetics
Protein Binding--drug effects
Protein Multimerization--drug effects
Proto-Oncogene Proteins c-myc--administration & dosage