Targeting excessive MYCN expression using MLN8237 and JQ1 impairs the growth of hepatoblastoma cells.

Eberherr, Corinna

Targeting excessive MYCN expression using MLN8237 and JQ1 impairs the growth of hepatoblastoma cells. [electronic resource] - International journal of oncology May 2019 - 1853-1863 p. digital

Publication Type: Journal Article

1791-2423

10.3892/ijo.2019.4741 doi


Adolescent
Azepines--pharmacology
Biomarkers, Tumor--genetics
Cell Line, Tumor
Cell Proliferation--drug effects
Child
Child, Preschool
DNA Methylation--drug effects
Early Detection of Cancer
Epigenesis, Genetic--drug effects
Female
Gene Expression Regulation, Neoplastic--drug effects
Hepatoblastoma--genetics
Humans
Infant
Infant, Newborn
Liver Neoplasms--genetics
Male
N-Myc Proto-Oncogene Protein--drug effects
Neoplasm Proteins--genetics
Pyrimidines--pharmacology
RNA, Antisense--genetics
Triazoles--pharmacology
Up-Regulation--drug effects