Double deletion of PINK1 and Parkin impairs hepatic mitophagy and exacerbates acetaminophen-induced liver injury in mice.

Wang, Hua

Double deletion of PINK1 and Parkin impairs hepatic mitophagy and exacerbates acetaminophen-induced liver injury in mice. [electronic resource] - Redox biology 04 2019 - 101148 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

2213-2317

10.1016/j.redox.2019.101148 doi


Animals
Biomarkers
Chemical and Drug Induced Liver Injury--etiology
Disease Models, Animal
Gene Deletion
Glutathione--metabolism
Hepatocytes--metabolism
JNK Mitogen-Activated Protein Kinases--metabolism
Male
Mice
Mice, Knockout
Mitochondria, Liver--genetics
Mitophagy--genetics
Models, Biological
Protein Kinases--genetics
Ubiquitin-Protein Ligases--genetics