Inhibition of Sphingosine Phosphate Receptor 1 Signaling Enhances the Efficacy of VEGF Receptor Inhibition.

Fischl, Anthony S

Inhibition of Sphingosine Phosphate Receptor 1 Signaling Enhances the Efficacy of VEGF Receptor Inhibition. [electronic resource] - Molecular cancer therapeutics 04 2019 - 856-867 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

1538-8514

10.1158/1535-7163.MCT-18-0548 doi


Angiogenesis Inhibitors--pharmacology
Animals
Antibodies, Monoclonal--pharmacology
Carcinoma, Renal Cell--blood supply
Cell Line, Tumor
Drug Therapy, Combination
Endothelial Cells--drug effects
Female
Humans
Kidney Neoplasms--blood supply
Lysophospholipids--antagonists & inhibitors
Male
Mice
Mice, Inbred C57BL
Mice, Nude
Neovascularization, Pathologic--drug therapy
Sphingosine--analogs & derivatives
Sphingosine-1-Phosphate Receptors--antagonists & inhibitors
Sunitinib--pharmacology
Treatment Outcome
Tumor Burden--drug effects
Vascular Endothelial Growth Factor A--pharmacology
Vascular Endothelial Growth Factor Receptor-2--antagonists & inhibitors
Xenograft Model Antitumor Assays