Loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation.

Guerrero-Gómez, David

Loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation. [electronic resource] - Cell death and differentiation 09 2019 - 1545-1565 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1476-5403

10.1038/s41418-018-0270-9 doi


Amyloid beta-Peptides--genetics
Animals
Autophagy--genetics
Basic Helix-Loop-Helix Transcription Factors--genetics
Caenorhabditis elegans--genetics
Caenorhabditis elegans Proteins--genetics
Cell Line
Endoplasmic Reticulum--metabolism
Glutathione--genetics
Glutathione Reductase--genetics
Homeostasis--drug effects
Humans
Maleates--pharmacology
Muscle Cells--metabolism
Neurons--metabolism
Oxidation-Reduction--drug effects
Peptides--antagonists & inhibitors
Phenotype
Protein Aggregation, Pathological--metabolism
Proteolysis--drug effects
Proteostasis--genetics
Saccharomyces cerevisiae--genetics
Sequestosome-1 Protein--genetics
alpha-Synuclein--genetics