Design, Synthesis, and Biological Evaluation of Novel DNA Gyrase-Inhibiting Spiropyrimidinetriones as Potent Antibiotics for Treatment of Infections Caused by Multidrug-Resistant Gram-Positive Bacteria.
Shi, Chenghui
Design, Synthesis, and Biological Evaluation of Novel DNA Gyrase-Inhibiting Spiropyrimidinetriones as Potent Antibiotics for Treatment of Infections Caused by Multidrug-Resistant Gram-Positive Bacteria. [electronic resource] - Journal of medicinal chemistry 03 2019 - 2950-2973 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1520-4804
10.1021/acs.jmedchem.8b01750 doi
Animals
Anti-Bacterial Agents--chemistry
DNA Gyrase--drug effects
Dogs
Drug Design
Drug Resistance, Multiple, Bacterial--drug effects
Gram-Positive Bacteria--drug effects
Gram-Positive Bacterial Infections--drug therapy
Humans
Mice
Microbial Sensitivity Tests
Rats
Spiro Compounds--chemistry
Structure-Activity Relationship
Topoisomerase II Inhibitors--chemistry
Design, Synthesis, and Biological Evaluation of Novel DNA Gyrase-Inhibiting Spiropyrimidinetriones as Potent Antibiotics for Treatment of Infections Caused by Multidrug-Resistant Gram-Positive Bacteria. [electronic resource] - Journal of medicinal chemistry 03 2019 - 2950-2973 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1520-4804
10.1021/acs.jmedchem.8b01750 doi
Animals
Anti-Bacterial Agents--chemistry
DNA Gyrase--drug effects
Dogs
Drug Design
Drug Resistance, Multiple, Bacterial--drug effects
Gram-Positive Bacteria--drug effects
Gram-Positive Bacterial Infections--drug therapy
Humans
Mice
Microbial Sensitivity Tests
Rats
Spiro Compounds--chemistry
Structure-Activity Relationship
Topoisomerase II Inhibitors--chemistry